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bromoacetonitrile manufacturers
bromoacetonitrile manufacturers
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samir123
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Nov 22, 2024
11:05 PM
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Sodium Triacetoxyborohydride
is an organobromine compound with the chemical formula C?H?BrN. It is a volatile and reactive chemical that plays an important role as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and other fine chemicals.
Chemical Structure and Properties
Chemical Name: Bromoacetonitrile
Molecular Formula: C?H?BrN
Molecular Weight: 118.95 g/mol
CAS Number: 590-17-0
Physical Properties:
Property Description
Appearance Colorless to pale yellow liquid
Melting Point -58°C
Boiling Point 102-104°C
Density 1.616 g/cm³
Solubility in Water Reacts with water
Solubility in Organic Solvents Soluble in solvents like ethanol, ether, and acetone
Bromoacetonitrile consists of a bromo group (-Br) attached to a carbon atom, which is also part of a nitrile group (-CN). This simple two-carbon structure makes the compound highly reactive, especially due to the presence of the electron-withdrawing nitrile group and the electron-attracting bromine atom.
Synthesis
Bromoacetonitrile can be synthesized through the bromination of acetonitrile, usually involving bromine (Br?) or a bromine source in the presence of catalysts. The reaction occurs at the methylene group (CH?) adjacent to the nitrile, introducing a bromine atom into the molecule.
Applications
Pharmaceutical Industry:
Bromoacetonitrile is used as an intermediate in the synthesis of various pharmaceutical compounds. It provides a reactive platform that can undergo further chemical transformations to introduce more complex molecular structures in drug development. For instance, it can be used in alkylation reactions or to introduce nitrile functionalities into drug candidates.
Agrochemicals:
In the agrochemical industry, bromoacetonitrile is employed in the synthesis of herbicides, fungicides, and pesticides. The reactivity of the nitrile and bromine groups makes it a valuable precursor for creating bioactive molecules that can protect crops from pests and diseases.
Organic Synthesis:
Bromoacetonitrile serves as a versatile reagent in organic synthesis. Its dual functional groups (bromo and nitrile) enable it to participate in various chemical reactions, including nucleophilic substitution and addition reactions. It can be used to introduce nitriles or bromoalkyl groups into organic molecules.
Polymer Chemistry:
Bromoacetonitrile can also be used in the functionalization of polymers, introducing reactive groups for further modification. It allows for the incorporation of nitrile groups into polymer backbones, which can be used to modify the physical properties of the material.
Reactions
Bromoacetonitrile can undergo several important reactions due to its dual functional groups:
Nucleophilic Substitution:
The bromine atom in bromoacetonitrile can be replaced by a nucleophile (such as an amine, thiol, or hydroxyl group), making it useful for creating various substituted acetonitrile derivatives.
Hydrolysis:
Bromoacetonitrile reacts with water to hydrolyze the nitrile group, yielding bromoacetamide or bromoacetic acid under acidic or basic conditions. This reaction is useful in generating carboxylic acid derivatives.
Grignard Reaction:
The nitrile group in bromoacetonitrile can react with Grignard reagents (organomagnesium halides), leading to the formation of ketones or other derivatives after subsequent hydrolysis.
Safety and Handling
Bromoacetonitrile is a hazardous substance and should be handled with caution. It is toxic if ingested, inhaled, or absorbed through the skin. Exposure to bromoacetonitrile can cause irritation to the respiratory system, skin, and eyes, and prolonged exposure can result in more severe health effects, including damage to the central nervous system.
Safety measures include:
Using appropriate personal protective equipment (PPE) such as gloves, safety goggles, and lab coats.
Working in a well-ventilated area or under a fume hood to minimize exposure to vapors.
Immediate washing with water in case of skin contact, and seeking medical attention if irritation persists.
Environmental Impact
Bromoacetonitrile can be harmful to aquatic life and should be disposed of following environmental regulations. It is essential to prevent the chemical from entering waterways or sewers, as it can cause contamination and long-term ecological damage. Waste containing bromoacetonitrile should be properly neutralized and disposed of in accordance with local environmental laws.
Conclusion
Bromoacetonitrile is a valuable chemical intermediate in the pharmaceutical, agrochemical, and polymer industries. Its reactivity, due to the presence of both a bromine atom and a nitrile group, makes it versatile for a wide range of synthetic applications. However, due to its toxicity and potential environmental impact, careful handling, storage, and disposal practices are necessary.
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