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1-boc Piperazine
1-boc Piperazine
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samir123
4 posts
Sep 28, 2024
1:38 AM
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1-Boc Piperazine
An Overview
1-Boc-piperazine, also known as tert-butoxycarbonyl piperazine, is an organic compound widely used in organic synthesis, particularly as a protected form of piperazine. The term "Boc" stands for tert-butoxycarbonyl, a protecting group used to shield the nitrogen atom of piperazine during chemical reactions, making 1-Boc-piperazine a crucial intermediate in pharmaceuticals, fine chemicals, and peptide synthesis.
Chemical Structure and Properties
Chemical Name: 1-Boc-piperazine
Molecular Formula: C?H??N?O?
Molecular Weight: 186.25 g/mol
CAS Number: 57260-71-6
Physical Properties:
Property Description
Appearance White crystalline powder or solid
Melting Point 40-42°C
Boiling Point 260°C (decomposes)
Solubility Soluble in organic solvents like ethanol, dichloromethane, and acetone
Stability Stable under normal conditions; reacts with acids or bases to remove Boc group
The structure of 1-Boc-piperazine features a piperazine ring in which one nitrogen is protected by a tert-butoxycarbonyl group (-Boc), making it unreactive during certain reactions where the piperazine core is being modified.
Applications
1-Boc-piperazine is widely used as a key intermediate in chemical synthesis, particularly in:
Pharmaceuticals: The Boc group is used to protect the nitrogen atom in piperazine during multi-step organic synthesis. Piperazine derivatives are found in various drug classes, including antihistamines, antipsychotics, and anti-infective agents. The Boc-protected form enables selective reactions on other parts of the molecule without interfering with the piperazine ring.
Peptide Synthesis: In peptide chemistry, the Boc group is a common nitrogen-protecting group, which can be removed under acidic conditions (such as treatment with trifluoroacetic acid). This allows for selective deprotection, enabling controlled stepwise peptide bond formation.
Organic Synthesis: 1-Boc-piperazine is often employed in the synthesis of complex organic molecules. The presence of the Boc group protects the amine from reacting prematurely, allowing chemists to perform transformations elsewhere in the molecule.
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