Penegra 50 mg, containing Sildenafil Citrate as its active ingredient, works to enhance erectile function primarily by increasing blood flow to the penis when a man is sexually stimulated. Here’s how Penegra 50 mg functions to improve erectile function:

Inhibition of PDE-5: Sildenafil Citrate, the active ingredient in Penegra 50 mg, is a type 5 phosphodiesterase (PDE-5) inhibitor. PDE-5 is an enzyme that breaks down cyclic guanosine monophosphate (cGMP), a substance that regulates blood flow in the penis. By inhibiting PDE-5, Sildenafil allows cGMP to persist longer, promoting relaxation of smooth muscles in the penile blood vessels.

Increased Blood Flow: During sexual stimulation, nitric oxide is released in the erectile tissue of the penis, which activates the enzyme guanylate cyclase. This enzyme increases levels of cGMP, which in turn relaxes the smooth muscles and dilates blood vessels in the penis. This dilation allows for increased blood flow into the erectile tissues, leading to an erection.

Erection Maintenance: With adequate sexual stimulation, Penegra 50 mg helps maintain the elevated levels of cGMP necessary for sustained penile blood flow and erection. It does not cause spontaneous erections but enhances the natural response to sexual stimulation.

Duration of Action: Penegra 50 mg typically starts working within 30 to 60 minutes after ingestion, though the onset may vary among individuals. Its effects can last for approximately 4 to 6 hours, during which time a man can achieve and maintain erections with sufficient sexual stimulation.

Improvement in Erectile Function: By facilitating improved blood flow to the penis and supporting the natural erectile response, Penegra 50 mg helps men with erectile dysfunction (ED) achieve and maintain erections firm enough for sexual intercourse. This enhancement in erectile function can lead to increased confidence, improved sexual satisfaction, and enhanced overall quality of life.