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What is the mechanism of action of Fildena 100 Mg?
What is the mechanism of action of Fildena 100 Mg?
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joniscosttale
Guest
Jun 13, 2024
11:25 PM
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Fildena 100 mg, like other medications for erectile dysfunction (ED) containing sildenafil citrate, works by blocking the enzyme phosphodiesterase type 5 (PDE5). Here's a detailed explanation of its mechanism of action:
Role of Nitric Oxide (NO): When a man is sexually stimulated, the release of nitric oxide (NO) in the erectile tissue of the penis triggers an enzyme called guanylate cyclase to produce cyclic guanosine monophosphate (cGMP).
Smooth Muscle Relaxation: cGMP is responsible for relaxing the smooth muscles in the blood vessels of the penis, allowing them to dilate and increase blood flow. This increased blood flow is essential for achieving and maintaining an erection.
Action of PDE5: Phosphodiesterase type 5 (PDE5) is an enzyme that breaks down cGMP, thereby reducing its concentration in the erectile tissue. Fildena 100 Mg process can prematurely end the erection by reducing blood flow to the penis.
Inhibition of PDE5: Sildenafil citrate, the active ingredient in Fildena 100 mg, selectively inhibits PDE5. By blocking this enzyme, sildenafil helps to maintain higher levels of cGMP in the erectile tissue. This prolongs the relaxation of smooth muscles and allows for sustained vasodilation, promoting a firmer and longer-lasting erection when sexually stimulated.
Timing and Effectiveness: Fildena 100 mg is typically taken orally about 30 minutes to 1 hour before anticipated sexual activity. It reaches its peak concentration in the bloodstream within 30 to 120 minutes after oral administration. The effects can last up to 4 to 5 hours, during which time it can facilitate multiple erections with sexual stimulation.
Overall, Fildena 100 mg enhances the natural physiological process involved in achieving an erection by increasing blood flow to the penis through inhibition of PDE5. It's important to note that sexual stimulation is necessary for the medication to be effective, as sildenafil alone does not cause an erection—it enhances the body's natural response to sexual arousal.
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